生发中心
滤泡树突状细胞
间质细胞
自身抗体
内科学
抗体
网状细胞
内分泌学
B细胞
化学
免疫系统
自身免疫
生物
分子生物学
免疫学
T细胞
医学
抗原提呈细胞
脾脏
作者
Alberto Hernández-Barranco,Vanesa Santos,Marina S. Mazariegos,Eduardo Caleiras,Laura Nogués,Frédéric Mourcin,Simon Léonard,Christelle Oblet,Steve Genebrier,Karin Tarte,Alberto Benguría,Alejandro F. Sanz,Enrique Vázquez,Ana Dopazo,Alejo Efeyan,Ana Ortega-Molina,Michel Cogné,Karin Tarte,Héctor Peinado
出处
期刊:Cell Reports
[Elsevier]
日期:2024-02-01
卷期号:43 (2): 113705-113705
被引量:1
标识
DOI:10.1016/j.celrep.2024.113705
摘要
Summary
Nerve growth factor receptor (NGFR) is expressed by follicular dendritic cells (FDCs). However, the role of NGFR in the humoral response is not well defined. Here, we study the effect of Ngfr loss on lymph node organization and function, demonstrating that Ngfr depletion leads to spontaneous germinal center (GC) formation and an expansion of the GC B cell compartment. In accordance with this effect, stromal cells are altered in Ngfr−/− mice with a higher frequency of FDCs, characterized by CD21/35, MAdCAM-1, and VCAM-1 overexpression. GCs are located ectopically in Ngfr−/− mice, with lost polarization together with impaired high-affinity antibody production and an increase in circulating autoantibodies. We observe higher levels of autoantibodies in Bcl2 Tg/Ngfr−/− mice, concomitant with a higher incidence of autoimmunity and lower overall survival. Our work shows that NGFR is involved in maintaining GC structure and function, participating in GC activation, antibody production, and immune tolerance.
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