重要事件
医学
信号转导
内科学
心脏病学
重症监护医学
细胞生物学
生物
历史
考古
作者
Satoru Eguchi,Keiichi Torimoto,Adebowale Adebiyi,Praghalathan Kanthakumar,Gisele Facholi Bomfim,Camilla F Wenceslau,Shelby Dahlen,Patrick Osei‐Owusu
出处
期刊:Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:2024-02-19
标识
DOI:10.1161/hypertensionaha.123.21365
摘要
To celebrate 100 years of AHA-supported cardiovascular disease research, this review article highlights milestone papers that have significantly contributed to the current understanding of the signaling mechanisms driving hypertension and associated cardiovascular disorders. This article also includes a few of the future research directions arising from these critical findings. To accomplish this important mission, 4 principal investigators gathered their efforts to cover distinct yet intricately related areas of signaling mechanisms pertaining to the pathogenesis of hypertension. The renin-angiotensin system, canonical and novel contractile and vasodilatory pathways in the resistance vasculature, vascular smooth muscle regulation by membrane channels, and noncanonical regulation of blood pressure and vascular function will be described and discussed as major subjects.
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