Intriguing link between fetal intracranial hemorrhage and X‐linked recessive chondrodysplasia punctata

Figure S1. Amino acid mutations mapped on the 3D model of ARSL. The protein structure is presented in brown ribbon, with the three glycine residues found in point mutations labeled and depicted in sphere representation, with carbon, nitrogen and oxygen atoms in green, blue and red, respectively. The active site residues are highlighted in colored sticks, and the calcium atom is represented as a magenta sphere. The two putative transmembrane a helices are displayed in light blue ribbon. This image was generated using PyMol (The PyMol Molecular Graphics System, Version 2.3.0, Schrödinger, LLC) through a similarity-based approach, employing the crystal structure of steryl-sulfatase as a template (gene STS, with 54.5% sequence identity, PDB ID 1P49), and Modeller10.1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.