Nanosecond Pulsed Bipolar Cancellation of the Killing Effect on Glioblastoma

Cell ablation experiments found that the electric field threshold of 3D (3D-like tissue) cell ablation (5.805 ± 1.455 kV/cm) is lower than that of monolayer wall cells (8.95 ± 0.75 kV/cm), which can cause a larger ablation area under the same pulsed electric field conditions. In addition, the BPC effect was more significant for 3D cells, but the trends of ablation area and BPC efficiency were similar when modulating the number of pulses.