Recent Advances in Asymmetric Synthesis of Chiral-at-Sulfur Sulfoximines

Sulfoximines with S-stereocenters have gained significant attention due to their diverse biological activities and growing applications in medicinal chemistry, agriculture, and materials science. Over the past two decades, substantial progress has been made in the development of synthetic methodologies for constructing S-stereogenic sulfoximines. Key strategies include transition-metal-catalyzed enantioselective C–H functionalization and asymmetric organocatalysis. Additionally, miscellaneous reactions involving addition/substitution processes with S-nucleophiles or S-electrophiles, such as sulfides, sulfoxides, sulfonimidates, sulfonimidoyl halides, and sulfenamides, offer alternative routes for synthesizing S-stereocenter sulfoximines. This Perspective aims to provide a comprehensive overview of the advancements made since 2010, emphasizing various synthetic approaches and their applications in the creation of S-stereogenic sulfoximines.