IFN-α affects Th17/Treg cell balance through c-Maf and associated with the progression of EBV- SLE

This study demonstrates that EBV infections may contribute to SLE development by activating STAT3 through IFN-α, inhibiting c-Maf, and causing Th17/Treg immune imbalance. Our work provided a new insight into the pathogenesis and treatment of SLE.