趋化因子
伤口愈合
活性氧
炎症
化学
单核细胞
癌症研究
血管生成
药理学
细胞生物学
免疫学
医学
生物化学
生物
作者
Yuan Peng,Dengming He,Xin Ge,Yifei Lü,Yuanhao Chai,Yixin Zhang,Zhengwei Mao,Gaoxing Luo,Jun Deng,Yan Zhang
标识
DOI:10.1016/j.bioactmat.2021.02.006
摘要
Excessive production of inflammatory chemokines and reactive oxygen species (ROS) can cause a feedback cycle of inflammation response that has a negative effect on cutaneous wound healing. The use of wound-dressing materials that simultaneously absorb chemokines and scavenge ROS constitutes a novel 'weeding and uprooting' treatment strategy for inflammatory conditions. In the present study, a composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol (starPEG) and heparin for chemokine sequestration as well as Cu5.4O ultrasmall nanozymes for ROS scavenging (Cu5.4O@Hep-PEG) was developed. The material effectively adsorbs the inflammatory chemokines monocyte chemoattractant protein-1 and interleukin-8, decreasing the migratory activity of macrophages and neutrophils. Furthermore, it scavenges the ROS in wound fluids to mitigate oxidative stress, and the sustained release of Cu5.4O promotes angiogenesis. In acute wounds and impaired-healing wounds (diabetic wounds), Cu5.4O@Hep-PEG hydrogels outperform the standard-of-care product Promogram® in terms of inflammation reduction, increased epidermis regeneration, vascularization, and wound closure.
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