生长激素受体
转基因小鼠
基因
转基因
生物
受体
内分泌学
内科学
遗传学
细胞生物学
生长激素
医学
激素
作者
Yanrong Qian,Darlene E. Berryman,Reetobrata Basu,Edward O. List,Shigeru Okada,J. A. Young,Elizabeth A. Jensen,Stephen Bell,Prateek Kulkarni,Silvana Duran‐Ortiz,Patricia Mora‐Criollo,Samuel Mathes,Alison Brittain,Mathew Buchman,Emily Davis,Kevin Funk,Jolie A Bogart,Diego Ibarra,Isaac Mendez-Gibson,Julie Slyby,Joseph Terry,John J. Kopchick
出处
期刊:Pituitary
[Springer Nature]
日期:2021-11-19
卷期号:25 (1): 1-51
被引量:21
标识
DOI:10.1007/s11102-021-01191-y
摘要
Much of our understanding of GH's action stems from animal models and the generation and characterization of genetically altered or modified mice. Manipulation of genes in the GH/IGF1 family in animals started in 1982 when the first GH transgenic mice were produced. Since then, multiple laboratories have altered mouse DNA to globally disrupt Gh, Ghr, and other genes upstream or downstream of GH or its receptor. The ability to stay current with the various genetically manipulated mouse lines within the realm of GH/IGF1 research has been daunting. As such, this review attempts to consolidate and summarize the literature related to the initial characterization of many of the known gene-manipulated mice relating to the actions of GH, PRL and IGF1. We have organized the mouse lines by modifications made to constituents of the GH/IGF1 family either upstream or downstream of GHR or to the GHR itself. Available data on the effect of altered gene expression on growth, GH/IGF1 levels, body composition, reproduction, diabetes, metabolism, cancer, and aging are summarized. For the ease of finding this information, key words are highlighted in bold throughout the main text for each mouse line and this information is summarized in Tables 1, 2, 3 and 4. Most importantly, the collective data derived from and reported for these mice have enhanced our understanding of GH action.
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