对映选择合成
化学
钯
亲核细胞
炔烃
芳基
催化作用
组合化学
药物化学
有机化学
立体化学
烷基
作者
Andrew Whyte,Jonathan Bajohr,Ramon Arora,Alexa Torelli,Mark Lautens
标识
DOI:10.1002/anie.202106518
摘要
Abstract An enantioselective consecutive cyclization/coupling process, catalyzed by palladium is reported. Stereoinduction arises from an enantioselective carbopalladation, generating an intermediate which promotes a nucleopalladation step. The dual cyclization sequence was compatible with a variety of alkyne‐tethered oxygen‐ and nitrogen‐centered nucleophiles, and a variety of alkenyl‐tethered aryl iodides, to forge numerous bisheterocycles in good yields and high regio‐ and enantioselectivities.
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