自噬
药物发现
小分子
药物开发
细胞生物学
计算生物学
生物
化学生物学
蛋白质降解
纳米技术
生物信息学
药品
生物化学
药理学
材料科学
细胞凋亡
作者
Thomas Whitmarsh-Everiss,Luca Laraia
标识
DOI:10.1038/s41589-021-00768-9
摘要
Autophagy is implicated in a wide range of (patho)physiological processes including maintenance of cellular homeostasis, neurodegenerative disorders, aging and cancer. As such, small molecule autophagy modulators are in great demand, both for their ability to act as tools to better understand this essential process and as potential therapeutics. Despite substantial advances in the field, major challenges remain in the development and comprehensive characterization of probes that are specific to autophagy. In this Review, we discuss recent developments in autophagy-modulating small molecules, including the specific challenges faced in the development of activators and inhibitors, and recommend guidelines for their use. Finally, we discuss the potential to hijack the process for targeted protein degradation, an area of great importance in chemical biology and drug discovery.
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