露西莉亚
生物
蛆虫
丽蝇科
转录组
基因
基因组
蝇蛆病
全基因组测序
基因组DNA
清创术(牙科)
遗传学
DNA测序
丘比特露西莉亚
幼虫
植物
医学
基因表达
口腔正畸科
作者
Rebecca J. Davis,Esther J. Belikoff,Allison N. Dickey,Elizabeth H. Scholl,Joshua B. Benoit,Maxwell J. Scott
出处
期刊:Genomics
[Elsevier]
日期:2021-11-01
卷期号:113 (6): 3978-3988
被引量:9
标识
DOI:10.1016/j.ygeno.2021.10.003
摘要
The common green bottle blow fly Lucilia sericata (family, Calliphoridae) is widely used for maggot debridement therapy, which involves the application of sterile maggots to wounds. The larval excretions and secretions are important for consuming necrotic tissue and inhibiting bacterial growth in wounds of patients. Lucilia sericata is also of importance as a pest of sheep and in forensic studies to estimate a postmortem interval. Here we report the assembly of a 565.3 Mb genome from long read PacBio DNA sequencing of genomic DNA. The genome contains 14,704 predicted protein coding genes and 1709 non-coding genes. Targeted annotation and transcriptional analyses identified genes that are highly expressed in the larval salivary glands (secretions) and Malpighian tubules (excretions) under normal growth conditions and following heat stress. The genomic resources will underpin future genetic studies and in development of engineered strains for genetic control of L. sericata and for biotechnology-enhanced maggot therapy.
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