Copper Catalyzed Direct Synthesis of Unsymmetrically Substituted Oxalamides From Bromodifluoroacetamide and Tertiary Amines

Abstract An efficient method for the synthesis of unsymmetrical oxalamides has been developed using bromodifluoroacetamide and tertiary amines under mild reaction conditions. This protocol provides a convenient and straightforward strategy for the rapid construction of various unsymmetrically N ‐substituted oxalamides moieties in a single step.