Rifampicin-Monoresistant Tuberculosis Is Not the Same as Multidrug-Resistant Tuberculosis: a Descriptive Study from Khayelitsha, South Africa
作者
Zubeida Salaam-Dreyer,Elizabeth M. Streicher,Frederick A. Sirgel,Fabrizio Menardo,Sònia Borrell,Miriam Reinhard,Anna Doetsch,Patrick Cudahy,Erika Mohr-Holland,Johnny Daniels,Anzaan Dippenaar,Mark P. Nicol,Sébastien Gagneux,Robin M. Warren,Helen Cox
L430P mutation, 7 were phenotypically susceptible using the critical concentration of 0.5 μg/ml (range, 0.125 to 1 μg/ml). The majority (215/230 [93.5%]) of RMR isolates showed susceptibility to all other TB drugs, highlighting the potential benefits of WGS for simplified treatment. These data suggest that the evolution of RMR-TB differs from MDR-TB with a potential contribution from HIV infection.