烯醇
糖苷
酮
民间医学
化学
传统医学
立体化学
医学
有机化学
催化作用
作者
Xiao-Xia Jie,Chang‐An Geng,Xiaoyan Huang,Yun‐Bao Ma,Xuemei Zhang,Rongping Zhang,Ji‐Jun Chen
出处
期刊:Fitoterapia
[Elsevier]
日期:2015-04-01
卷期号:102: 96-101
被引量:13
标识
DOI:10.1016/j.fitote.2015.02.009
摘要
Five new secoiridoid glycosides, swericinctosides A and B (1–2), 9-epi swertiamarin (3), 2′-O-m-hydroxybenzoyl swertiamarin (4), 4″-O-acetyl swertianoside E (5), and one unusual lactonic enol ketone, 3-(hydroxymethyl ene) dihydro-2H-pyran-2, 4(3H)-dione (6), together with three known compounds, swertiaside (7), swertianoside C (8) and decentapicrin B (9) were isolated from Swertia cincta. The structures of the new compounds were determined by extensive spectroscopic analyses including 1D and 2D NMR, HRESIMS, UV, IR and [α]D spectra. Anti-HBV assay on HepG 2.2.15 cell line in vitro demonstrated that compounds 1–9 possessed inhibitory activity on HBV DNA replication with IC50 values from 0.05 to 1.83 mM, and compounds 1, 3, 5, 7 and 8 could inhibit the secretion of HBsAg with IC50 values from 0.24 to 1.06 mM.
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