染色质
生育率
精子
流式细胞术
生物
DNA
男科
男性生育能力
变性(裂变材料)
精液
遗传学
化学
人口
医学
核化学
环境卫生
作者
Donald P. Evenson,Zbigniew Darzynkiewicz,Myron R. Melamed
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1980-12-05
卷期号:210 (4474): 1131-1133
被引量:743
标识
DOI:10.1126/science.7444440
摘要
Flow cytometry of heated sperm nuclei revealed a significant decrease in resistance to in situ denaturation of spermatozoal DNA in samples from bulls, mice, and humans of low or questionable fertility when compared with others of high fertility. Since thermal denaturation of DNA in situ depends on chromatin structure, it is assumed that changes in sperm chromatin conformation may be related to the diminished fertility. Flow cytometry of heated sperm nuclei may provide a new and independent determinant of male fertility.
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