胞磷胆碱
医学
神经保护
药物输送
缺血
磁共振成像
麻醉
药理学
放射科
内科学
材料科学
纳米技术
作者
Fangjingwei Xu,Hongbin Han,Junhao Yan,He Chen,Qichun He,Weiguo Xu,Ning Zhu,Hong Zhang,Fugen Zhou,Kejia Lee
出处
期刊:Drug Delivery
[Informa]
日期:2011-09-16
卷期号:18 (7): 461-467
被引量:28
标识
DOI:10.3109/10717544.2011.589084
摘要
Limited penetration of neuroprotective drug citicoline into the central nervous system (CNS) by systemic administration led to poor efficiency. A novel method of stereotactic drug delivery was explored to make citicoline bypass the blood brain barrier (BBB) and take effect by direct contact with ischemic neurons. A permanent middle cerebral artery occlusion (pMCAO) model of rats was prepared. To get the optimal conditions for citicoline administration by the novel stereotactic delivery pathway, magnetic resonance imaging (MRI) tracer method was used, and a dose-dependent effect was given. Examinations of MRI, behavior evaluation, infarct volume assessment and histological staining were performed to evaluate the outcome. This MRI-guided stereotactic delivery of citicoline resulted in a notable reduction (>80%) in infarct size and a delayed ischemic injury in cortex 12 hours after onset of acute ischemia when compared with the systematic delivery. The improved neuroprotective efficiency was realized by a full distribution of citicoline in most of middle cerebral artery (MCA) territory and an adequate drug reaction in the involved areas of the brain. Brain lesions of treated rats by stereotactic delivery of citicoline were well predicted in the lateral ventricle and thalamus due to a limited drug deposition by MRI tracer method. Our study realized an improved neuroprotective efficiency of citicoline by stereotactic delivery, and an optimal therapeutic effect of this administration pathway can be achieved under MRI guidance.
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