纳米技术
化学
X射线
光子上转换
材料科学
体内
放射化学
控制释放
按需
电离辐射
PEG比率
辐照
辐射
生物物理学
辐射敏感性
核医学
氧气增强率
辐射损伤
光电子学
发光
计算机科学
光学
物理
生物技术
经济
生物
多媒体
财务
作者
Wenpei Fan,Wenbo Bu,Zhen Zhang,Bo Shen,Hui Zhang,Qianjun He,Dalong Ni,Zhaowen Cui,Kuaile Zhao,Jiwen Bu,Jiulin Du,Jianguo Liu,Jianlin Shi
标识
DOI:10.1002/anie.201504536
摘要
Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs in vitro and in vivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.
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