CONTINUOUS DIRECT COMPRESSION USING PORTABLE CONTINUOUS MINIATURE MODULAR & MANUFACTURING (PCM&M)

Chapter 22 CONTINUOUS DIRECT COMPRESSION USING PORTABLE CONTINUOUS MINIATURE MODULAR & MANUFACTURING (PCM&M) Daniel O. Blackwood, Daniel O. Blackwood Drug Product Design, Pfizer, Groton, CT, USASearch for more papers by this authorAlexandre Bonnassieux, Alexandre Bonnassieux Drug Product Design, Pfizer, Groton, CT, USASearch for more papers by this authorGiuseppe Cogoni, Giuseppe Cogoni Analytical R&D, Pfizer, Groton, CT, USASearch for more papers by this author Daniel O. Blackwood, Daniel O. Blackwood Drug Product Design, Pfizer, Groton, CT, USASearch for more papers by this authorAlexandre Bonnassieux, Alexandre Bonnassieux Drug Product Design, Pfizer, Groton, CT, USASearch for more papers by this authorGiuseppe Cogoni, Giuseppe Cogoni Analytical R&D, Pfizer, Groton, CT, USASearch for more papers by this author Book Editor(s):Mary T. am Ende, Mary T. am Ende Lyndra Therapeutics, Inc., Watertown, MA, USASearch for more papers by this authorDavid J. am Ende, David J. am Ende Nalas Engineering Services, Inc., Centerbrook, CT, USASearch for more papers by this author First published: 29 March 2019 https://doi.org/10.1002/9781119600800.ch72Citations: 9 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary Portable Continuous Miniature Modular (PCMM) technology has recently been created for the development and manufacture of solid oral dosage forms using continuous direct compression or continuous wet granulation technologies. This chapter presents a brief discussion and overview of the key features of the PCMM system, and describes the features of the horizontal and vertical in-line mixers. The characterization of in-line powder mixers has been described with three key statistics, including mean residence time, residence time distribution, and total blade passes. Additionally, the chapter describes empirical studies on the impact of material properties and process parameters on the residence time distribution of powders within each of these systems. In conjunction with gravimetric feeders, the in-line powder mixers serve as a critical unit operation in achieving a uniform blend prior to downstream granulation steps or conversion into a dosage form. Citing Literature Chemical Engineering in the Pharmaceutical Industry: Active Pharmaceutical Ingredients, Second Edition RelatedInformation