突触发生
雷特综合征
神经科学
转录组
生物
自闭症
长非编码RNA
精神分裂症(面向对象编程)
自闭症谱系障碍
表观遗传学
智力残疾
神经可塑性
心理学
基因
遗传学
精神科
基因表达
核糖核酸
作者
Ebrahim Hosseini,Zahra Bagheri‐Hosseinabadi,Ilario De Toma,Moslem Jafarisani,Iman Sadeghi
标识
DOI:10.1016/j.mam.2019.07.004
摘要
In the last decade, transcriptome analyses have discovered thousands of long non-coding RNAs (lncRNAs) which are assumed as a fundamental part of the gene regulatory networks in the cell. Intriguingly, lncRNAs are abundantly enriched in the brain, displaying elaborate spatiotemporal expression profiles and modulation. They diversely participate in the delicate regulation of the central nervous system (CNS) development including self-renewal maintenance, cell fate decision, synapse plasticity, synaptogenesis and memory formation. Moreover, lncRNAs have vastly demonstrated correlations with mental illnesses such as neuropsychiatric disorders (NPDs), implying the vital jobs of these yet poorly-understood transcripts. Here, we underlie the accumulating evidence for the significance of lncRNAs in neural networks and their impairment in several NPDs including autism spectrum disorder (ASD), schizophrenia (SZ), intellectual disability (ID), major depressive disorder (MDD), Rett syndrome (RTT) and others.
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