细胞内
菌丝体
锌
氧化应激
抗氧化剂
化学
抗真菌
抗菌剂
纳米颗粒
机制(生物学)
生物物理学
氧化磷酸化
酶
生物化学
微生物学
生物
材料科学
纳米技术
有机化学
植物
哲学
认识论
作者
Fengqin Zhang,Xiongduo Liu,Myima Pentok,Elingarami Sauli,Nongyue He,Xiangli Zen,Xiaolong Li,Tonghua Liu
标识
DOI:10.1166/jbn.2019.2718
摘要
Although zinc oxide nanoparticles are known as an effective antimicrobial agent, the mechanism for its antifungal activity has been assessed by only few studies. In this study, antifungal activity mechanism for ZnO via the change of physiology was explored. It was showed that the activities of SOD and CAT and the MDA content were increased significantly. The possible mechanisms were obtained that zinc oxide directly acts on the mycelium of penicillium to produce oxidative stress and destroy intracellular physiological balance. RNA-seq was then used to verify the conclusion obtained before, and obtained results suggested that the antifungal mechanism is attributed to oxidative stress and changes in membrane function.
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