Twip公司
材料科学
血小板
合金
背景(考古学)
腐蚀
冶金
晶体孪晶
内科学
生物
医学
微观结构
古生物学
作者
Carole Verhaegen,Sophie Lepropre,Marie Octave,Davide Brusa,Luc Bertrand,Christophe Beauloye,Pascal Jacques,Joëlle Kefer,Sandrine Horman
出处
期刊:Journal of Biomaterials and Nanobiotechnology
[Scientific Research Publishing, Inc.]
日期:2019-01-01
卷期号:10 (04): 175-189
被引量:5
标识
DOI:10.4236/jbnb.2019.104010
摘要
A current challenge concerns developing new bioresorbable stents that combine optimal mechanical properties and biodegradation rates with limited thrombogenicity.In this context, twinning-induced plasticity (TWIP) steels are good material candidates.In this work, the hemocompatibility of a new TWIP steel was studied in vitro via hemolysis and platelet activation assessments.Cobalt chromium (CoCr) L605 alloy, pure iron (Fe), and magnesium (Mg) WE43 alloy were similarly studied for comparison.No hemolysis was induced by TWIP steel, pure Fe, or L605 alloy.Moreover, L605 alloy did not affect CD62P exposure, αIIbβ3 activation at the platelet surface, or phosphorylation of protein kinase C (PKC) substrates upon thrombin stimulation.In contrast, TWIP steel and pure Fe significantly decreased platelet response to the agonist.Given that similar inhibitory effects were obtained when using a conditioned medium previously incubated with TWIP steel, we postulated TWIP steel corrosion to be likely to release components counteracting platelet activation.We showed that the main ion form present in the conditioned medium is Fe 3+ .In conclusion, TWIP steel resorbable scaffold displays anti-thrombogenic properties in vitro, which suggests that it could be a promising platform for next-generation stent technologies.
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