Challenging structural applications such as customized jet engine parts are increasingly fabricated by Selective Laser Melting (SLM) of Inconel 718 powder. The as-built surface quality of SLM parts is however inferior of the machined version and the fatigue behavior is negatively affected. The as-built fatigue response of SLM Inconel 718 was quantified here using three sets of directional specimens. Since the surface quality is influenced by powder characteristics, process parameters and layer-wise fabrication, fatigue results showed a directional contribution that was interpreted using metallography and fractography.