化学
姜黄素
槲皮素
多酚
抗氧化剂
螯合作用
生物活性
水溶液中的金属离子
组合化学
金属
体外
生物化学
有机化学
作者
Eleftherios Halevas,Anna Pekou,Rigini Papi,Barbara Mavroidi,Antonios G. Hatzidimitriou,Georgia Zahariou,G. Litsardakis,Marina Sagnou,Maria Pelecanou,Αnastasia A. Pantazaki
标识
DOI:10.1016/j.jinorgbio.2020.111083
摘要
Curcumin and quercetin are two of the most prominent natural polyphenols with a diverse spectrum of beneficial properties, including antioxidant, anti-inflammatory, chemopreventive and chemotherapeutic activity. The complexation of these natural products with bioactive transition metal ions can lead to the generation of novel metallodrugs with enhanced biochemical and pharmacological activities. Within this framework, the synthesis and detailed structural and physicochemical characterization of two novel complex assemblies of Cu(II) with curcumin and quercetin and the ancillary aromatic chelator 2,2′-bipyridine is presented. The two complexes represent the only crystallographically characterized structures with Cu(II) as the central metal ion and curcumin or quercetin as the ligands. The new complexes were biologically evaluated in vitro for their antioxidant potential, both exhibiting strong scavenging activity in the 2,2-diphenyl-1-picrylhydrazyl assay, and their plasmid DNA binding/cleavage properties. Both complexes appear to be non-toxic in the eukaryotic experimental model Saccharomyces cerevisiae and merit further investigation of their pharmacological profile.
科研通智能强力驱动
Strongly Powered by AbleSci AI