暴发型
心肌炎
医学
病因学
病理生理学
重症监护医学
细胞激素风暴
临床试验
急性心肌炎
机制(生物学)
心脏病学
生物信息学
内科学
病理
疾病
2019年冠状病毒病(COVID-19)
传染病(医学专业)
哲学
认识论
生物
作者
Weijian Hang,Chen Chen,John M. Seubert,Dao Wen Wang
标识
DOI:10.1038/s41392-020-00360-y
摘要
Fulminant myocarditis (FM) is characterized by a rapid progressive decline in cardiac function and a high mortality rate. Since the first report of FM patients in the 1980s, several clinical trials and research studies have been published increasing our knowledge regarding FM. Currently, the diagnosis of FM depends on various techniques including electrocardiography, echocardiography, endomyocardial biopsy, and cardiac magnetic resonance. The development of mechanical circulation support (MCS) devices and progress in our understanding of the pathophysiological mechanisms underlying FM, treatment regimens have evolved from simple symptomatic treatment to a life support-based comprehensive treatment approach. The core mechanism underlying the development of FM is the occurrence of an inflammatory cytokine storm. This review provides a comprehensive account of the current understanding of FM pathophysiology and knowledge regarding its etiology, pathophysiology, treatments, and outcomes.
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