嗜酸乳杆菌
益生菌
嗜热链球菌
医学
胰岛素抵抗
双歧杆菌
随机对照试验
2型糖尿病
糖尿病
乳酸菌
2型糖尿病
短双歧杆菌
内科学
内分泌学
生物
食品科学
细菌
发酵
遗传学
作者
Kelly A. Tiderencel,Deborah A. Hutcheon,Jane Ziegler
摘要
Summary With the increasing prevalence of type 2 diabetes mellitus (T2DM), there is increased interest in probiotic supplementation for improving glycaemic control. This review evaluates nine randomized controlled trials that tested the effects of probiotics on glycaemic outcomes including fasting plasma glucose, fasting plasma insulin, haemoglobin A1c, and homeostatic model assessment of insulin resistance among adults with T2DM. Based on the evidence reviewed, multistrain probiotics that contain seven million to 100 billion colony forming units of Lactobacillus acidophilus , Streptococcus thermophilus , Lactobacillus bulgaricus , and/or Bifidobacterium lactis administered for 6 to 12 weeks may be efficacious for improving glycaemic control in adults with T2DM. Further research is needed to understand the role of the gut microbiota and the probiotic dose, medium, and duration of exposure that is most effective for disease management.
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