神经化学
乙酰胆碱酯酶
内分泌学
内科学
脂质过氧化
阿切
行为绝望测验
医学
药理学
氧化应激
化学
生物化学
酶
抗抑郁药
海马体
作者
Laraib Liaquat,Saara Ahmad,Sadia Sadir,Zehra Batool,Saima Khaliq,Saiqa Tabassum,Shaista Emad,Syeda Madiha,Sidrah Shahzad,Saida Haider
出处
期刊:PubMed
日期:2017-03-01
卷期号:30 (2(Suppl.)): 647-653
被引量:7
摘要
Alzheimer's disease (AD) is an age-related neurodegenerative disorder associated with neurochemical and neurobehavioural alterations. Aluminium (Al) is considered as a contributing factor in the etiology of several neurodegenerative disorders like AD. D-galactose (D-gal) is a physiological nutrient but over supply induces some neurochemical and biochemical changes that exacerbate natural aging process. In this study, we aimed to develop AD animal model by co-administration of Al and D-gal in rats. Male albino Wistar rats were intraperitoneally injected with AlCl3 and D-gal at a dose of 150mg/kg and 300mg/kg respectively for one week. After one week rats were subjected to behavioural analysis. After behavioural analysis rats were decapitated to remove their brain. Biochemical and neurochemical analysis were conducted in whole brain. AlCl3+D-gal significantly induced depressive and anxious behaviour in rats. Rats cognitive abilities were also significantly impaired following AlCl3 and D-gal co-administration. AlCl3+D-gal significantly altered antioxidant enzyme activities and biogenic amine levels in whole brain. A marked increase in brain lipid peroxidation and acetylcholinesterase activity was found in test rats. These findings suggest that co-administration of AlCl3 and D-gal for one week could induce AD like symptoms and may be used to develop AD animal model.
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