RNA Interference: An Evolutionary Pathway in Periodontal Tissue Engineering

RNA interference (RNAi) is an evolutionary conserved silencing pathway in which the double-stranded RNA is broken down into small interfering RNA (siRNA) with the help of dicer and RNA-induced silencing complex (RISC) complex by a series of steps. Pioneering observations on RNAi were reported in plants, but later on RNAi-related events were described in almost all eukaryotic organisms, including protozoa, flies, nematodes, insects, parasites, and mouse and human cell lines.