缺氧(环境)
生物
谷氨酰胺
活性氧
细胞生物学
营养物
葡萄糖摄取
氧气
生物化学
化学
内分泌学
生态学
氨基酸
胰岛素
有机化学
作者
Michael S. Nakazawa,Brian Keith,M. Celeste Simon
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2016-09-23
卷期号:16 (10): 663-673
被引量:313
摘要
Oxygen availability, along with the abundance of nutrients (such as glucose, glutamine, lipids and albumin), fluctuates significantly during tumour evolution and the recruitment of blood vessels, leukocytes and reactive fibroblasts to complex tumour microenvironments. As such, hypoxia and concomitant nutrient scarcity affect large gene expression programmes, signalling pathways, diverse metabolic reactions and various stress responses. This Review summarizes our current understanding of how these adaptations are integrated in hypoxic tumour cells and their role in disease progression.
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