Tumor Lysis SyndromeTumor lysis syndrome (TLS) is a condition that occurs when a large number of cancer cells die within a short period, releasing their contents in to the blood.How Does TLS Affect the Body?When cancer cells break down quickly in the body, levels of uric acid, potassium, and phosphorus rise faster than than the kidneys can remove them.This causes TLS.Excess phosphorus can "sop up" calcium, leading to low levels of calcium in the blood.Changes in blood levels of uric acid, potassium, phosphorus, and calcium can affect the functioning of several organs, especially the kidneys, and also the heart, brain, muscles, and gastrointestinal tract.