Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts

Objective. The transcription factor peroxisome proliferator-activated receptor (PPAR)-γ plays an important role in controlling cell differentiation. The aim of the present study was to examine whether PPAR-γ expression was reduced in skin scleroderma fibroblasts and whether PPAR-γ agonists could suppress the persistent fibrotic phenotype of skin scleroderma fibroblasts.