微气泡
聚焦超声
超声波
共焦
血脑屏障
次谐波
生物医学工程
材料科学
声发射
传感器
压电
共焦显微镜
声学
医学
中枢神经系统
光学
物理
内分泌学
非线性系统
复合材料
量子力学
作者
Chih-Hung Tsai,Jiawei Zhang,Yixiang Liao,Hao-Li Liu
标识
DOI:10.1088/0031-9155/61/7/2926
摘要
Burst-tone focused ultrasound exposure in the presence of microbubbles has been demonstrated to be effective at inducing temporal and local opening of the blood-brain barrier (BBB), which promises significant clinical potential to deliver therapeutic molecules into the central nervous system (CNS). Traditional contrast-enhanced imaging confirmation after focused ultrasound (FUS) exposure serves as a post-operative indicator of the effectiveness of FUS-BBB opening, however, an indicator that can concurrently report the BBB status and BBB-opening effectiveness is required to provide effective feedback to implement this treatment clinically. In this study, we demonstrate the use of subharmonic acoustic emission detection with implementation on a confocal dual-frequency piezoelectric ceramic structure to perform real-time monitoring of FUS-BBB opening.
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