Objective:To observe the therapeutic effect of Huangqi Danggui Mixture (HDM)combined with western medicine for the treatment of diabetic nephropathy(DN). Methods:Sixty DN patients were equally randomized into two groups:the control group received routine western medicine and the treatment group received HDM combined with western medicine. Results:The remarkably effective rate was 45.16% and the total ef- fective rate was 87.09% in the treatment group,and the remarkably effective rate was 20.00% and the total effective rate was 56.67% in the control group,the difference be- ing significant between the two groups(P0.01). After treatment,blood urea nitrogen (BUN),serum creatinine(SCr)and 24-hour urinary,protein were decreased in the treatment(P0. 01),and the differences of SCr and 24-hour urinary protein were sig- nificant between the two groups(P0. 05). Fasting blood glucose(FBG),total choles- terol(TC)and triglyceride(TG)in the two group were also decreased(P0.01 com- pared with those before treatment). Conclusion:Huangqi Danggui Mixture combined with western medicine is effective for the treatment of diabetic nephropathy by decreasing the urinary,protein ad blood lipid,and by improving renal function.