Expression of Prostate Stem Cell Antigen and Prostate Special Antigen in Prostate Adenocarcinoma Tissues and Its Significance

Objective To campare the expression of prostate stem cell antigen(PSCA) with that of prostate special antigen(PSA) in different prostatic tissues and the prostate adenocarcinoma tissues at different Gleason value levels.Methods Fifty-one cases of prostate adenocarcinoma,16 of prostatic intraepithelial neoplasms and 18 of benign prostatic hyperplasia were examined and analyzed by the SP immunohistochemical staining.Results There were significant differences of expressions of PSCA and PSA among prostate adenocarcinoma and prostate intraepifhelial and benign prostate hyerplasia(P0.05),however there was no difference between the expressions of the two antigens in prostate cancer tissues(P0.05).Conclusion It is possible for PSCA to become a new marker of the diagnosis of prostate adenocarcinoma in molecular pathology and a hot point of research.in the immunotheraphy of prostate adenocarcinoma.