Objective To evaluate the curative effect of antibiotic for ventilator-associated pneumonia(VAP)infected with stenotrophomonas maltophilia(SM)and provide the evidences for treat- ment.Methods 72 patients were involved in this study and divided into two groups:non-treated group and treated group with antibiotic.To compare the prognosis of patients in two groups.Results There were 34 patients in the non-treated group:5 were cured,14 showed obvious improvement and 15 were ineffec- five;there were 38 patients in antibiotic treated group:7 were cured,19 showed obvious improvement and 12 were ineffective.There were no significant differences in results between the two groups(χ~2=1.20,P0.05).Conclusion There was no evidence that antibiotics are effective for ventilator-associated pneu- monia infected with stenotrophomonas maltophilia.