【Objective】To investigate the main factors that cause the enucleation of eyeball in clinical setting. 【Methods】We retrospectively reviewed all the patients with enucleation of eyeballs in our hospital from January 2003 to November 2010.【Results】The most common cause of destructive procedure was trauma(34.4%), followed by neoplasms(29.5%), and infection(27.5%). Regarding neoplasms, females were more likely to be enucleated while the reverse was so for traumas and infection(all P 0.05). 【Conclusions】The most common reason to cause the enucleation of eyeballs was trauma. Men were much frequently involved in the eyeball enucleation with reasons of trauma and infection, while in the cases with neoplasms, their amount was less than women's. The key points of reducing the occurrence rate of enucleation are to increase the awareness of family accident and improve the early diagnosis of ocular neoplasms.