A meta-analysis of the effectiveness of 5% Imiquimod cream made in china in the treatment of Genital warts

Objective:To evaluate the efficacy and safety of 5% imiquimod cream made in China in the treatment of genital warts. Methods:The CNKI and CBMDisc were searched.The randomized controlled trials(RCT) comparing 5% imiquimod cream versus placebo or fluorouracil cream were included,and two authors independently reviewed the data and assessed the quality.The data were inputted and analyzed by RevMan 4.2.8 software supplied by the Cochrane Collaboration.Results:Among imiquimod cream mono-treatment groups eight trials ranked high quality were included.Meta-analysis of the treatment of genital warts with 5% imiquimod cream showed the clinical effective rates were significantly different between 5% imiquimod cream and placebo,while were not between 5% imiquimod and 2.5% fluorouracil cream.No serious systematical adverse reaction was recorded.Among imiquimod cream combined with physiotherapy groups,twelve trials ranked high quality were included.Meta-analysis of the treatment of genital warts with 5% imiquimod cream combined with physiotherapy showed the clinical effective rates were significantly different between 5% imiquimod cream and placebo.Conclusion:5% imiquimod cream is an effective and safe agent for the treatment of genital warts;topically using 5% imiquimod cream is effective in preventing genital warts relapse after physiotherapy.