Investigation of the liver failure patients infected with hepatitis B virus treated with entecavir

Objective To observe the therapeutic effects and its safety of entecavir on the patients of liver failure with hepatitis B virus infection.Methods The treatment group(n=30) were administered 0.5mg entecavir orally once daily based upon basic supportive therapy.The survival rate,liver function,complications and serum HBVDNA viral load 1 year after treatment were observed and compared with that of the matched controls.Results The survival rate in the treatment group and control were 70.00% and 43% respectively and the survival rate of the treatment group was significantly higher than that of the controls(x2=4.34,P0.05).The improvement of liver function and serum HBV DNA viral load at undetectable level at 1year after therapy in enticavir treatment group was significantly higher than that of controls.Morbidity of complications in the treatment group with a good drug safety was superior to that in controls.Conclusion Entecavir showed its positive effect and safety on the improvement of the survival rate and the life quality in patients with hepatitis B liver failure.