Celecoxib vs ibuprofen in treating osteoarthritis

AIM:To compare the therapeutic effects and safety of celecoxib and ibuprofen in treating osteoarthritis. METHODS: Sixty-six patients with osteoarthritis were divided into two groups.Celecoxib group of thirty-four patients received celecoxib 100 mg, po, bid, for 4 wk. Ibuprofen group of thirty-two patients received ibuprofen 300 mg, po, bid, for 4 wk. RESULTS: The total effective rates were 85 % in celecoxib group and 81 % in ibuprofen group(P 0.05). The adverse reaction rates were 18 % in celecoxib group and 34 % in ibuprofen group(P 0.05). CONCLUSION: Celecoxib is an effective and safe drug in treating osteoarthritis.