Effect of Shenqi Fuzheng Injection on the Hematopoietic Function of Mouse after Chemo-Therapy

Objective To explore the effect of Shenqi Fuzheng Injection on the hematopoietic function of mouse after chemo-therapy. Methods 5-FU (225 mg/kg) induced bone marrow depression mouse model was used for the study. Mice of therapeutic group were given Shenqi Fuzheng Injection 5 ml/kg every day and the control ones were injected with saline. After one week, the mice were killed and blood cell count, cultivation of hemopoietic progenitor cells, and pathological examination of the bone marrow were performed. Results Shenqi Fuzheng Injection could increase peripheral blood cell count: The counts of RBC,WBC and PLT in treated mice were higher than in the control ones(P 0.05). Promote the proliferation of HPC: the counts of CFU-GM, CFU-E and CFU-MK colonies of the treated mice were higher than that in the control ones(P 0.05).Improve the bone marrow inhibition: pathological examination showed in the control group, the hematopoietic structure was destroyed and there were few hematopoietic cells, while in treated group the structure of bone marrow was rather intact and filled with abundant of hematopoietic cells. Conclusion Shenqi Fuzheng injection can improve proliferation of hematopoietic tissue and blood cells by stimulating growth of hemopoietic progenitor cell in mouse whose bone marrow and hematopoietic function was suppressed after chemotherapy.