Through the investigation of biological laboratory safety management standards and operating manuals from several research institutes and universities in the U.S.A.,the U.S.biological laboratory safety management programs and biosecurity measures were introduced,including the basic concepts of laboratory management,laboratory biosafety and laboratory biosecurity,and laboratory biorisk evaluation criteria.Taking the BSL3-level biology laboratory as an example,the specific implementation plan was discribed.Finally,several suggestions for biosafety management in China were presented based on the laboratory bisafety management experience gained in the U.S.A and the laboratory biosafety situation in China.