血管生成
伤口愈合
交感神经系统
受体
医学
再生(生物学)
肾上腺素能的
微血管
神经科学
病理
生物
内分泌学
内科学
细胞生物学
免疫学
血压
作者
Liangli Pan,Jianbing Tang,Hongwei Liu,Biao Cheng
出处
期刊:Clinical Hemorheology and Microcirculation
[IOS Press]
日期:2016-03-18
卷期号:62 (2): 181-191
被引量:16
摘要
Angiogenesis is essential for wound healing, and angiogenesis impairment can result in chronic ulcers. Studies have shown that the sympathetic nervous system has an important role in angiogenesis. In recent years, researchers have focused on the roles of sympathetic nerves in tumor angiogenesis. In fact, sympathetic nerves can affect angiogenesis in the wound healing of soft tissues, and may have a similar mechanism of action as that seen in tumorigenesis. Sympathetic nerves act primarily through interactions between the neurotransmitters released from nerve endings and receptors present in target organs. Among this, activation or inhibition of adrenergic receptors (mainly β-adrenergic receptors) influence formation of new blood vessels considerably. As sympathetic nerves locate near pericytes in microvessel, go along the capillaries and there are adrenergic receptors present in endothelial cells and pericytes, sympathetic nerves may participate in angiogenesis by influencing the endothelial cells and pericytes of new capillaries. Studying the roles of sympathetic nerves on the angiogenesis of wound healing can contribute to understanding the mechanisms of tissue repair, tissue regeneration, and tumorigenesis, thereby providing new therapeutic perspectives.
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