Oxidation- and thermo-responsive poly(N-isopropylacrylamide-co-2-hydroxyethyl acrylate) hydrogels cross-linked via diselenides for controlled drug delivery

A novel diselenide crosslinked poly(NIPAM-co-HEA) hydrogel was successfully synthesized, which exhibits a dual-stimuli-responsive drug release behaviors,i.e., thermo-induced slow sustained release and oxidation-induced quick burst release.