髓鞘少突胶质细胞糖蛋白
免疫学
实验性自身免疫性脑脊髓炎
抗体
多发性硬化
自身免疫
发病机制
医学
脑脊髓炎
抗原
自身免疫性疾病
髓鞘
中枢神经系统
生物
内分泌学
作者
Patrice H. Lalive,Nicolas Molnarfi,Mahdia Benkhoucha,Martin Weber,Marie-Laure Santiago-Raber
标识
DOI:10.1016/j.jneuroim.2011.09.005
摘要
Neurological deficit in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis is widely considered to be a consequence of synergistic T and B cell responses to central nervous system (CNS) antigens. We show that mice immunized with encephalitogenic myelin oligodendrocyte glycoprotein (MOG(35-55)) peptide develop significant serum levels of anti-MOG antibodies in parallel with disease progression. Furthermore, EAE mice developed antibodies against DNA and RNA, a serological hallmark observed in autoimmune diseases such as systemic lupus erythematosus. The presence of anti-nucleic responsive B cells and antibodies during EAE may highlight a previously unappreciated mechanism in the pathogenesis of CNS autoimmunity.
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