Clinical pharmacokinetics and pharmacodynamics : concepts and applications

Preface Definition of Symbols Non-Proprietary and Brand Names of Drugs in Text and Illustrations I. Basic Considerations *1. Therapeutic Relevance *2. Fundamental Concepts and Terminology II. Exposure and Response after a Single Dose *3. Kinetics Following an Intravenous Bolus Dose *4. Membranes and Distribution *5. Elimination *6. Kinetics Following an Extravascular Dose *7. Absorption *8. Response Following a Single Dose III. Therapeutic Regimens *9. Therapeutic Window *10. Constant-Rate Input *11. Multiple Dose Regimens IV. Individualization *12.Variability *13.Genetics *14. Age, Weight, and Gender *15. Disease *16. Nonlinearities *17. Drug Interactions *18. Initiating and Managing Therapy V. Supplemental Topics *19. Distribution Kinetics *20. Metabolites and Drug Response *21. New! Protein Drugs *22. New! Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data Appendices A. Assessment of AUC B. Ionization and the pH Partition Hypothesis C. Distribution of Drugs Extensively Bound to Plasma Proteins D. Plasma-to-Blood Concentration Ratio E. Well-stirred Model of Hepatic Clearance F. Absorption Kinetics G. Wagner-Nelson Method H. Mean Residence Time I. Amount of Drug in Body on Accumulation to Plateau J. Answers to Study Problems