A state of the art review on the synthesis, antibacterial, antioxidant, antidiabetic and tissue regeneration activities of zinc oxide nanoparticles

Recently, zinc oxide nanoparticles (ZnONPs) are gaining much interest of nanobiotechnologists due to their profound biomedical applications. ZnONPs are used as antibacterial agents, which cause both gram-positive and negative bacterial cell death through the generation of reactive free radicals as well as membrane rupture. ZnONPs show excellent antioxidant properties in normal mammalian cells via the scavenging of reactive free radicals and up-regulation of antioxidant enzyme activities. Besides, it also shows hypoglycaemic effect in diabetic animals via pancreatic β-cells mediated increased insulin secretion and glucose uptake by liver, skeletal muscles and adipose tissues. Among the other potential applications, ZnONPs-induced bone and soft-tissue regeneration open a new horizon in the field of tissue engineering. Here, first we reviewed the complete synthesis routes of ZnONPs by physical, chemical, and biological pathways as well as outlined the advantages and disadvantages of the techniques. Further, we discussed the several important aspects of physicochemical analysis of ZnONPs. Additionally, we extensively reviewed the important biomedical applications of ZnONPs as antibacterial, antioxidant, and antidiabetic agents, and in the field of tissue engineering with special emphasis on their mechanisms of actions. Furthermore, the future perspectives of the ZnONPs are also discussed.