单核苷酸多态性
优势比
等位基因
基因型
糖尿病性视网膜病变
SNP公司
医学
内科学
遗传模型
等位基因频率
病例对照研究
胃肠病学
多态性(计算机科学)
置信区间
遗传学
作者
Huijuan Xu,Huan Li,Qian Luo,Yihui Li,Guo Huang,Chuntao Lei,Fang Hao,Jialing Xiao,Chen Yang,Man Yu,Ziyang Wang,Yi Shi,Ling Zhong,Lixin Duan,Huafu Chen,Yao Dezhong,Bo Gong,Zhenglin Yang
标识
DOI:10.1080/13816810.2021.1946702
摘要
Genetic factors have been studied to be associated with diabetic retinopathy (DR). This study aimed to investigate the association between the polymorphisms in the osteoproterin (OPG) gene and DR in a Han Chinese population.There were 475 patients with diabetic retinopathy (DR), 478 type 2 diabetes mellitus without retinopathy (DNR) and 469 healthy controls collected in this study. OPG single-nucleotide polymorphisms (SNPs) rs2073618 and rs3134069 were genotyped by Mass ARRAY MALDI-TOF system. The genotype and allele frequencies were evaluated using the χ2 tests. Odds ratio (OR) and 95% confidence intervals (95% CI) were calculated for the risk of genotype and allele.There was a statistically significant difference for OPG SNP rs3134069 between DR cases and healthy controls in the allelic model (P = .036, OR = 1.33, 95% CI = 1.02-1.73). The C allele frequency of this polymorphism was 0.154 in the DR cases, whereas it was 0.120 in healthy controls, suggesting a risk effect for DR. SNP rs3134069 had a significant association with DR in the dominant model (P = .038, OR = 1.37, 95% CI = 1.02-1.84), indicating that the CC/AC genotype was more likely to suffer from DR. For rs2073618, no significant difference was identified in the allelic model (P = .632, OR = 0.95, 95% CI = 0.78-1.16) and the four genetic models.This study showed that OPG SNP rs3134069 was associated with DR in the dominant model, suggesting that the OPG gene variant may be involved in the development of DR.
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