SULT1A1 (Minoxidil Sulfotransferase) enzyme booster significantly improves response to topical minoxidil for hair regrowth

Abstract Background Minoxidil is a widely used over‐the‐counter topical treatment for hair loss. The response rate for topical minoxidil is relatively low. Minoxidil is a pro‐drug, converted to its active form, minoxidil sulfate, by SULT1A1 enzymes located in the scalp. Recently, a novel topical formula that increases the activity of SULT1A1 in hair follicles was reported. Aims To evaluate any benefit of applying the SULT1A1 enzyme booster prior to daily 5% minoxidil treatment. Methods Male androgenic alopecia patients were recruited to a randomized blinded placebo‐controlled study. Patients were randomized to receive 5% topical minoxidil plus the novel formula or minoxidil plus a sham adjuvant. Patient's hair growth was monitored using global photography over 60 days. Results Twenty‐four males with androgenic alopecia (Norwood scale average 4.4, range 2–6) were randomized and completed the trial: 12 in the active arm and 12 in placebo. 75% of the subjects who used the SULT1A1 adjuvant with their daily minoxidil treatments for 60 days regrew hair versus 33% of those using the placebo adjuvant ( p = 0.023). Conclusions In a small cohort of androgenetic alopecia men, adding the SULT1A1 adjuvant to their daily minoxidil treatment regimen improved hair regrowth.