姜黄素
细胞凋亡
神经母细胞瘤
化学
细胞周期检查点
细胞周期
细胞内
药理学
信号转导
癌症研究
细胞生物学
生物
生物化学
细胞培养
遗传学
作者
Zijie Ye,Danyang Chen,Zheng Ren,Haiyang Chen,Tiantian Xu,Changbing Wang,Shi-En Zhu,Xin Gao,Jin Zhang,Dian Li,Yueyin Pang,Bing Zhu,Yinghua Li,Wei Hua Jia
摘要
Neuroblastoma (NB) is a solid tumor in the nervous system and has a high mortality rate in children. Curcumin has well-characterized anticancer properties, while there is no effective method in clinical treatment. MTT assays revealed that curcumin dramatically inhibited the proliferation of SK-N-SH cells. Compared with the control group, curcumin markedly restrained the migration of SK-N-SH cells. Curcumin induced SK-N-SH cell apoptosis by G2/M cycle arrest and activated caspase-3 activity. Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl-2 signal pathways. This finding demonstrated the application of curcumin is an effective strategy for the therapeutics of NB.
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