Structural Aspects of Nucleation Inhibitors for Diastereomeric Resolutions and the Relationship to Dutch Resolution

You say you want a resolution: Nucleation inhibitors for the resolution of diastereomers by selective crystallization have been designed and tested. The resolution of racemic 3-methoxyphenylethylamine was optimized with (S)-mandelic acid as the resolving agent (see scheme). Multifunctional inhibitors are particularly effective. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704021_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.