拉明
生物
核板
中间灯丝
疾病
早衰
细胞生物学
功能(生物学)
核心
遗传学
计算生物学
核蛋白
细胞骨架
细胞
病理
基因
转录因子
医学
作者
Veronika Butin‐Israeli,Stephen A. Adam,Anne E. Goldman,Robert D. Goldman
标识
DOI:10.1016/j.tig.2012.06.001
摘要
Recent studies have shown that premature cellular senescence and normal organ development and function depend on the type V intermediate filament proteins, the lamins, which are major structural proteins of the nucleus. This review presents an up-to-date summary of the literature describing new findings on lamin functions in various cellular processes and emphasizes the relationship between the lamins and devastating diseases ranging from premature aging to cancer. Recent insights into the structure and function of the A- and B- type lamins in normal cells and their dysfunctions in diseased cells are providing novel targets for the development of new diagnostic procedures and disease intervention. We summarize these recent findings, focusing on data from mice and humans, and highlight the expanding knowledge of these proteins in both healthy and diseased cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI